This monograph attempts to clarify one significant but much neglected aspect of Peirce's contribution to the philosophy of science. It was written in 1963 as my M. A. thesis at the Uni versity of Illinois. Since the topic is still neglected it is hoped that its pUblication will be of use to Peirce scholars. I should like to acknowledge my indebtedness to Dr. Max Fisch who broached this topic to me and who advised me con tinuously through its development, assisting (...) generously with his own insights and unpublished Peirce manuscripts. TABLE OF CONTENTS INTRODUCTION 1. A Current Issue in the Philosophy of Science 1 2. Peirce and His Theory of Abduction 5 3. The General Character of Abduction 7 PART I: THE EARLY THEORY 1. Peirce's Earliest Conception of Inference 11 2. Three Kinds of Inference and Three Figures of Syllogism 13 3. Ampliative Inference and Cognition 17 4. Induction and Hypothesis 20 5. The Method of Methods 23 PART II: THE LATER THEORY 1. The Transitional Period 28 2. Three Stages of Inquiry 31 3. Abduction and Guessing Instinct 35 4. Logic as a Normative Science 38 5. Hypothesis Construction and Selection 41 6. Abduction and Pragmatism 44 7. Economy of Research 47 8. Justification of Abduction 51 CONCLUSION 55 61 BIBLIOGRAPHY INTRODUCTION 1. (shrink)

Prior apparently left a substantially completed manuscript dealing with the objects of thought when he died in 1969. Geach and Kenny have edited this material, supplementing it with both published and unpublished other writings, including an appendix on names in lieu of Prior's intended final chapter. The result is an interesting, often non-standard, discussion of many issues central to philosophical logic. There are two major concerns treated--what is it that we think?, and what is it that we think about?. These (...) are the two principle ways in which 'thinking of' can occur as a relation for Prior. An examination of the first sense results in a defense of the view that propositions, as language-independent logical constructions, are the objects of thought. In doing so, a large number of related issues are discussed to include criticisms of extentionalist [[sic]] theses, a sympathetic version of the assertive redundancy theory of truth, and an account of non-assertoric logic. Prior also devotes chapters to paradoxes such as that of the liar, and to Tarskian and alternative semantics. Perhaps the most interesting section of the book is that devoted to discussing what sentences are about, especially when their ostensible subjects are non-existent, e.g., "The King of France is bald." It is not clear just what his positive views are, but Prior has a number of criticisms directed against current intentionalistic views of names as well as against Russellian names. His chief worry seems to concern oratio obliqua constructions in which a reporter does not believe in the existence of that of which/whom a reportee speaks. Although critical of writers influenced by either the early Brentano or the later Russell, Prior appears to be sympathetic to both schools in that he seems to view non-demonstrative sentences as never being directly about their subjects. Thus, neither "Gustavus is bald" nor "The King of Sweden is bald" would be about the King of Sweden, i.e., Gustavus. However, since Gustavus is the King of Sweden, the sentences are indirectly about him. Presumably, such a move precludes a reporter's being committed to the reportee's ontology, thereby avoiding the difficulty. An interesting but undeveloped aspect of his view is the role of background stories in our use of names. While some use is made of formal logic in the Polish notation, unfamiliarity with either is not a bar to following the text as English translations and keys are provided. It is unfortunate that we cannot look forward to further elucidation of Prior's views.--K. T. (shrink)

Meiotic recombination occurs preferentially at certain regions called hot spots and is important for generating genetic diversity and proper segregation of chromosomes during meiosis. Hot spots have been characterized most extensively in yeast, mice and humans. The development of methods based on sperm typing and population genetics has facilitated rapid and high‐resolution mapping of hot spots in mice and humans in recent years. With increasing information becoming available on meiotic recombination in different species, it is now possible to compare several (...) molecular features associated with hot‐spot loci. Further, there have been advances in our knowledge of the factors influencing hot‐spot activity and the role that they play in structuring the genome into haplotype blocks. We review the molecular features associated with hot spots in terms of their properties and mechanisms underlying their function and distribution. A large number of these features seem to be shared among hot spots from different species suggesting common mechanisms for their formation and function. BioEssays 28:45–56, 2006. © 2005 Wiley Periodicals, Inc. (shrink)

The history of contemporary modal logic dates back to the writings of C. S. Lewis in the early part of this century. Since then, a growing body of literature has attested to professional interest in the area, and in a number of related issues in philosophical logic which have received wide attention. The recent development of powerful formal techniques for modal system building, together with an increasing interest in modal logic as a tool for philosophical analysis, have created a need (...) for an up-to-date text to introduce students to this material. Snyder's book attempts to answer this need. Assuming an understanding of elementary propositional logic, Snyder introduces a reductive technique called cancellation for detecting the theorems of a system of logic. This technique, analogous to the construction of Smullyan trees but more compact, is extended to modal and quantified contexts. Cancellation versions of the systems M and Mn of G. H. von Wright, and S4 and S5 of Lewis are developed. Snyder uses a Hintikka type of semantics, showing how the various formal systems are differentiated at the semantic level by differing conditions which must be imposed on the model systems used as interpretations for them. These model systems, and the conditions imposed upon them, are in turn described by means of a metalanguage which is essentially first-order quantificational logic. The power of this technique stems from the fact that for every object language formula of a system, there is a corresponding formula in the metalanguage which describes the conditions an interpretation must meet in order to satisfy the original formula. The conditions that the interpretations of a given system of logic must meet are reflected in this metalanguage as "antecedent assumptions," and these in turn correspond to cancellation rules for the object language. This correspondence is constructed in such a way that the metalinguistic counterpart of each theorem of the system will be a theorem of first-order logic. Snyder's primary interest is in showing how modal logic can be used, with the help of these techniques, to build a large variety of formal systems and to "tailor" such systems to meet a variety of analytical tasks. Simple modal systems are developed for the articulation of a number of modal concepts, in addition to the classic alethic ones. Examples are taken from temporal, deontic, and epistemic logic to show how specific interpretations of the meanings of the relevant operators lead to the incorporation of appropriate conditions in the formal systems used to articulate them. An entire chapter is devoted to a discussion of the paradoxes of material and strict implication, and to an attempt to articulate the notion of entailment through the development of formal systems which include a dyadic modal operator that is free of these paradoxes. The final chapter discusses such classical issues as proper names, reference, fictional entities, definite descriptions, and existence presuppositions. Appendices deal with such matters as the equivalence of the cancellation systems to more classical axiomatic-deduction systems, and the sketch of a proof of soundness and completeness for all the modal systems presented. While designed as a text, this volume should be of interest to both logicians and those working in metaphysics and language analysis, since the primary concern of the author is to develop techniques that will facilitate the usefulness of modal logic as a tool for philosophical analysis. The instructor's manual contains many suggestions derived from the author's experience in teaching this non-standard treatment of the subject.--K. T. (shrink)

The twenty-two essays collected for this book range widely in theme, style, and quality. The essays, a majority of which were previously unpublished, are arranged in three sections: 1) Early Essays, containing one particularly fine essay, "The Soul at Play," originally intended as part of Santayana's Soliloquies in England; 2) Later Essays, in which the title essay and "Friendship" are outstanding; and 3) Philosophical Essays, offering commentaries on Russell, Dewey, and James, on his own philosophy, and "On the False Steps (...) of Philosophy." The book's last article, "What is the Ego?", is an elaboration of his criticism of those "German Prophets" who return from self-contemplation "as greedy as children and as stubborn as Inquisitors." Santayana's manner of exposition often involves the elaboration of a single image or metaphor. When an image or metaphor is employed which can bear the weight of subtle distinctions, he is brilliant; but when the metaphor is too weak to encompass his thinking, then his writing becomes flowery and decadent. The essays, unfinished and fragmentary for the most part, are frequently little more than a single extended metaphor--sometimes over-extended. The fragmentary, possibly only experimental, ideas in these essays invite comparison with their use in his completed works. The book will be of special interest to someone already familiar with Santayana.--A. K. T. (shrink)

JL Austin exercised in Post-war Oxford an intellectual authority similar to that of Wittgenstein in Cambridge. Although he completed no books of his own and published only seven papers, Austin became through lectures and talks one of the acknowledged leaders in what is called ‘Oxford philosophy’ or ‘ordinary language philosophy’. Few would dispute that among analytic philosophers Austin stands out as a great and original philosophical genius. Three volumes of his writing, published after his death, have become classics in analytical (...) philosophy: _Philosophical Papers_; _Sense and Sensibilia_; and _How to Do Things with Words_. First published in 1979, this book is a collection of critical essays on Austin’s philosophy written by well-known philosophers, many of whom knew Austin personally. A number of essays included were especially written for this volume, but the majority have appeared previously in various journals or books, not all easy to obtain. (shrink)

The double issue of Synthese devoted to essays on the work of W. V. Quine has been re-issued under hard cover with an additional paper by Grice on "Vacuous Names" and a 13-page bibliography of Quine's writings. With the exception of Berry's "Logic with Platonism" and Jensen's "On The Consistency of a Slight. Modification of Quine's New Foundation," the papers are concerned with the key issues of Word and Object. Quine's responses to each of the contributors are not as helpful (...) as they might be, but are at times quite illuminating. He dispels Stenius's view in "Beginning with Ordinary Things" that Quine holds a Russellian epistemology, for example, and clarifies somewhat his account of ontic commitment in replying to Hintikka's "Behavioral Criteria of Radical Translation." Hintikka argues that "to be is to be a value of a bound variable" presupposes the principle, "to be is to be an object of search." Quine rejects this view, identifying his ontology with the range of the variables as opposed to the class of all things to which a theory is ontically committed. The introduction to chapter two of Word and Object by Harman is quite helpful, suggesting among other things that Quine's use of 'propositional attitude' is a misnomer to be better replaced by 'sentential attitude'. An interesting and provocative paper by Kaplan offers a Fregean alternative to Quine's general mode of handling referentially opaque contexts, allowing "Quantifying In" with the variable ranging over expressions. Interestingly enough, Quine's remarks are rather laudatory and sympathetic. Davidson's "On Saying That" suggests a roughly similar account of oratio obliqua discourse. Føllesdal and Sellars discuss "Quine on Modality" and "Some Problems about Belief." There is a discussion of "Quine's Philosophy of Science" by Smart, tracing a shift from instrumentalism to realism on the part of Quine. Also included are papers by Chomsky, Stroud, and Geach, as well as Strawson's familiar "Singular Terms and Predication." In spite of the imposing price and the uneven quality of the essays, the book is a desirable piece of Quineana.--K. T. (shrink)

Graphical AbstractGroup photo of the participants at the chromosome stability meeting in Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India. The meeting brought together the Indian scientific community and investigators from other countries working on various aspects of chromosome stability.

On April 3, 1995, the Fourth Circuit upheld the right of a Maryland hospital to terminate a surgeon who was HIV-positive ). A resident in the University of Maryland Neurosurgical Training Program was dismissed when hospital administrators learned of his infection with HIV. The resident, known as Dr. Doe, claimed that his termination violated federal laws protecting persons with disabilities. The court upheld the hospital's actions as lawful and affirmed the trial court's grant of summary judgment for the hospital.Dr. Doe (...) charged that his dismissal from the training program violated the Rehabilitation Act and the Americans with Disabilities Act. (shrink)

Prophets are messengers in charge of communicating the orders and prohibitions they received from God. Throughout history, there are those who believe in these prophets as well as those who do not. While the thought rejecting prophethood sometimes manifested itself as a trend, sometimes it came out on a personal basis. For example, the "Berâhime", known to be of Indian origin, and the "Sümeniyya" movement, which has different rumors about its origin, can be given as examples. Again, it can be (...) said that the current of thought emerging under the name of “Deism” serves this purpose. On the other hand, personalities such as Abu Isa al-Verrâq, Ibn al-Rawendi and Abu Bakr ar-Razi, It is known that they objected to the prophethood of the Prophet. Although Ibn al-Rawendi was a scholar of Mu'tezile at first, he later left this idea and put forward mulhidish ideas. In addition to he tried to cancel the Hz Mohammed's prophethood. While Ibn al-Rawendi was doing this, sometimes he emphasized the miracles of the Prophet and sometimes claimed that there were some deficiencies and contradictions in the rhetoric of the Quran. According to Ibn al-Rawendi, there are many contradictory information in the Quran. According to him, unnecessary repetitions, unnecessary prolongation of the word in some places and the presence of non-Arabic origin words show that the Quran is not a miracle book and cannot be described as universal. Qâdî Abdulcabbâr, one of the scholars of Mu'tezile, handled these objections with great care and answered them. The number of such discussions in Kalam sources is quite high. For example, there are such polemics in Imam Mâturîdî's Kitâbü't-Tevhîd and in Bâkillânî's Kitâbü't-Temhîd. In this study, the discussion in the 16th volume of al-Muğnî of Qadi Abdulcabbâr will be discussed. In the aforementioned discussion, Qadı Abdulcabbâr firstly stated Ibn al-Rawendi's objection to the Qur'an, and then duly eliminated this objection. The most striking point here is that Ibn al-Rawendi ignored the features of the Arabic language, the integrity of the Quran and that it has a purpose while making these criticisms. For this reason, while presenting the criticisms, he severed the verses from their contexts, did not consider the before and after, and therefore did not understand or understand the message correctly. On the other hand, Qadı Abdulcabbâr gave convincing answers by linking the criticized verses with their contexts and revealing the real meaning. (shrink)